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Tolfedine 20mg Tablets

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Quick Overview

Anti-inflammatory tablets containing 20mg tolfenamic acid

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Details

Characteristics:

Tolfenamic acid is a non steroidal anti-inflammatory drug (NSAID) belonging to the fenamate class.

Major mechanisms of action involved are suggested to be:

  • Inhibition of cyclo-oxygenase: the enzyme which uses arachidonic acids as substrate, leading to the formation of inflammatory mediators such as prostaglandins E2 and I2.
  • Inhibition of lipo-oxygenase: the enzyme leading to the synthesis of leucotrienes.
  • Inhibition of some eicosanoids by action at the receptor levels.
  • Inhibition of chemotaxis of polymorphonuclear cells.
  • The existence of an enterohepatic cycle has been shown.

Uses:

Anti-inflammatory

Cats: Treatment of acute and chronic inflammatory conditions. Analgesic and antipyretic.

Dogs: Treatment of acute and chronic inflammatory conditions. Analgesic and antipyretic.

Dosage and Administration:

The recommended dosage is 4mg of tolfenamic acid per kg bodyweight once daily by oral administration with food.

Each 20mg tablet treats 5kg bodyweight.

Tolfedine® tablets may be used as an alternative to Tolfedine® 4% injection.

A suggested administration regime is an initial treatment with Tolfedine® 4% followed 24 or 38 hours later by Tolfedine® tablets for up to 3 days. Enterohepatic circulation of tolfenamic acid has been demonstrated and may account for its prolonged activity in cats and dogs.

Contra-Indications:

Do not use in animals receiving corticosteroids or other NSAIDs.

Do not use in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding, where there is evidence of blood dyscrasia. Avoid use in dehydrated, hypovolemic or hypotensive animals as there is a potential risk of increased renal toxicity. Use in animals under 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided, animals may require a reduced dosage and careful clinical management.

Presentation:

Boxes of 16 & 96 tablets in blister packs.

Store in a dry place below 25°C.

Prescription only medicine.

Keep out of reach of children.

 

Registered pursuant to the ACVM Act 1997, No A7623

RESTRICTED VETERINARY MEDICINE

Tolfedine 20mg Tablets - For Animal Treatment Only

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